In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease.
Open Access
- 1 February 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 56 (2) , 185-192
- https://doi.org/10.1001/archpsyc.56.2.185
Abstract
ALZHEIMER DISEASE (AD) results in substantial loss of brain tissue.1-15 This decline is attributable to deterioration of cell processes, shrinkage of neurons, and perhaps neuronal death.10,16-20 Healthy elderly individuals show an age-related gray matter volume decline in the neocortex21-24 (see Guttman et al25) but their volume loss may not be accompanied by neuronal death.26-29 At issue is the functionality of the tissue remaining in the brains of healthy elderly patients and patients with AD.Keywords
This publication has 36 references indexed in Scilit:
- White matter changes with normal agingNeurology, 1998
- Selective Cortical and Hippocampal Volume Correlates of Mattis Dementia Rating Scale in Alzheimer DiseaseArchives of Neurology, 1997
- Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matterCerebral Cortex, 1997
- Morphology and Neurochemical Characteristics of the Vulnerable Neurons in Brain Aging and Alzheimer’s DiseaseEuropean Neurology, 1997
- Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age‐associated memory impairmentNeurology, 1994
- A Quantitative Magnetic Resonance Imaging Study of Changes in Brain Morphology From Infancy to Late AdulthoodArchives of Neurology, 1994
- Neurofibrillary tangle densities in the hippocampal formation in a non-demented population define subgroups of patients with differential early pathologic changesNeuroscience Letters, 1993
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991
- Alzheimer disease: measuring loss of cerebral gray matter with MR imaging.Radiology, 1991
- Cerebral structure on MRI, Part I: Localization of age-related changesBiological Psychiatry, 1991