Carotid sinus reflex influence on plasma renin activity

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Abstract
The influence of carotid sinus hypotension on plasma renin activity [PRA] was studied in salt-deprived, vagotomized, anesthetized dogs whose aortic blood pressure was held constant. Bilateral carotid occlusion during the experimental period decreased carotid sinus pressure to 79 mm Hg. PRA increased significantly within 5 min and reached 161% of control 20 min after occlusion began and remained elevated until the occlusion was released. Bilateral carotid occlusion with a venous shunt lowered carotid pressure to 15 mm Hg, and PRA increased significantly within 5 min and reached 175% of control 20 min after the occlusion began. In the sham-occlusion group and in the group with denervated carotid sinuses. PRA decreased slightly throughout the experiment. When the groups with and without venous shunting were compared to the sham-occlusion group there was a statistically significant increase in PRA (P < 0.01 and P < 0.05, respectively). There was no significant difference in PRA between the sham group and the group with denervated carotid sinuses. Carotid sinus hypotension results in a rapid, sustained reflex increase in PRA and this response originates in the carotid sinus area.

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