Effects of Iron on Extracellular and Intracellular Growth of Penicillium marneffei
Open Access
- 1 March 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (3) , 1724-1726
- https://doi.org/10.1128/iai.68.3.1724-1726.2000
Abstract
Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.Keywords
This publication has 20 references indexed in Scilit:
- Different susceptibilities of yeasts and conidia ofPenicillium marneffeito nitric oxide (NO)-mediated fungicidal activity of murine macrophagesClinical and Experimental Immunology, 1998
- The Heme Moiety of Malaria Pigment (β-Hematin) Mediates the Inhibition of Nitric Oxide and Tumor Necrosis Factor-α Production by Lipopolysaccharide-Stimulated MacrophagesExperimental Parasitology, 1995
- The role of iron in infectionCurrent Opinion in Infectious Diseases, 1995
- Iron regulates nitric oxide synthase activity by controlling nuclear transcription.The Journal of Experimental Medicine, 1994
- Disseminated Penicillium marneffei infection in Southeast AsiaThe Lancet, 1994
- Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis.Journal of Clinical Investigation, 1994
- Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. In vitro and in vivo animal studies.Journal of Clinical Investigation, 1993
- Penicillium Marneffei: Dimorphism and TreatmentPublished by Springer Nature ,1993
- High-performance liquid chromatography of siderophores from fungiBioMetals, 1988
- IRON ABSORPTION AND TRANSPORT IN MICROORGANISMSAnnual Review of Nutrition, 1981