A STUDY OF GRANULOCYTIC PROGENITOR CELLS (CFC) IN BONE-MARROW TRANSPLANTATION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 25  (4) , 235-239
Abstract
Granulocytic progenitor cells (CFC) are a better reflection of stem cell pools than precursors. Their total number can be estimated during hematologic steady-state (n = 70 .+-. 29 .times. 105 CFC/kg); the amount of marrow necessary to perform a bone marrow transplantation is only 1% of the total pool. CFC are useful but have a mainly qualitative value in evaluating the viability of marrow stored for 24 h at room temperature (92%) or marrow thawed after DMSO [dimethylsulfoxide] cryopresevation (62%). Sequential study of CFC in patients receiving autologous marrow transplantation enables differentiation of engraftment from autologous recovery. In 11 recipients of autologous marrow transplantation, no statistical relation was observed between number of infused CFC and severity of granulocytopenia. Further studies will be necessary to evaluate a better marker of real hematopoietic stem cells.