Enzymatic ring expansion of penicillins to cephalosporins: side chain specificity
- 1 January 1987
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 5,p. 374-375
- https://doi.org/10.1039/c39870000374
Abstract
Structural variants on the acylamino-side chains of penicillins as substrates for the ring expansion enzyme from Cephalosporium acremonium CO728 show that a six carbon chain terminating in a carboxy group permits efficient conversion into cephems with the exception of δ-(L-α-aminoadipoly)[5-(5S)-amino-5-carboxypentanoyl].Keywords
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