The effect of antioxidants on the hydrolytic and oxidative degradation of sulphacetamide in aqueous solutions

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Abstract
The effect of heat and light stresses on the degradation of sulphacetamide solutions at pH 7, in the presence and absence of the antioxidants sodium metabisulphite and sodium edetate, have been investigated. Sodium metabisulphite accelerates the hydrolytic degradation of sulphacetamide to sulphanilamide, whereas sodium edetate does not change the rate. The absorption peak causing colour development due to heat stress is shown to differ from that due to light stress. The development due to both stimuli has been measured quantitatively with time. Sulphanilamide present in heat-degraded solutions is shown to be insignificant in the development of colour due to heat stress, but to have a major role in colour formation under light stress.

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