Evaluation of the Mineralocorticoid Activity of 18-Hydroxycorticosterone
- 1 August 1981
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 61 (2) , 201-206
- https://doi.org/10.1042/cs0610201
Abstract
1. The mineralocorticoid activity of 18-hydroxycorticosterone (18-OH-B) has been compared with that of aldosterone by using human bioassay in vivo with measurement of rectal potential difference and urinary log 10 Na+/K+ ratio. 2. A log-linear relationship was found between maximum change in rectal potential difference and increasing doses of aldosterone. 3. No mineralocorticoid activity could be demonstrated after an intravenous bolus and infusion of 18-OH-B. 4. The half-life of clearance of 18-OH-B was measured in three subjects and found to be 28, 48 and 24 min.Keywords
This publication has 2 references indexed in Scilit:
- Simultaneous Measurement of Secretory Rates of Aldosterone and 18-HydroxycorticosteroneJournal of Clinical Endocrinology & Metabolism, 1965
- THE DISAPPEARANCE OF 7-H3-d-ALDOSTERONE IN THE PLASMA OF NORMAL SUBJECTS*Journal of Clinical Investigation, 1961