Interleukin 2, production in the syngeneic mixed lymphocyte reaction

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Abstract
In the syngeneic mixed lymphocyte reaction, Ly 1 cells proliferate following stimulation with Ia‐positive macrophage‐like cells. The proliferation is accompanied by the release of interleukin 2 into the medium. Both the proliferation and interleukin 2 production are dependent on the expression of Ia antigenic determinants, as the addition of haplotype‐specific anti‐Ia antisera to the cultures inhibits both parameters.