SKIN AND BONE-LESIONS (DERMATO-OSTEOLATHYRISM), POSSIBLE SIDE-EFFECTS OF D-PENICILLAMINE TREATMENT, IN A BOY WITH CYSTINURIA

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 34  (3) , 281-291
Abstract
Strychnine, a potent antagonist of glycine was given to twins suffering from nonketotic hyperglycinemia at age 73 h. Within hours of the onset of treatment favorable effects were observed such as improvements of muscle tone, movements, defense reactions and probably breathing. Pyridoxine, N5-formyl-tetrahydrofolate and lipoic acid were given concomitantly with strychnine but failed to alter glycine levels in plasma and CSF. The therapeutic trial was terminated after 2 1/2 days because success, although considerable, was judged inadequate.