Renal tubular acidosis in primary Sjögren's syndrome
- 1 June 1992
- journal article
- Published by Springer Nature in Clinical Rheumatology
- Vol. 11 (2) , 226-230
- https://doi.org/10.1007/bf02207962
Abstract
Renal tubular acidosis (RTA) is a frequent extraglandular manifestation of Sjögren's syndrome; however, no distinction on the incidence of this renal tubular defect between primary and secondary Sjögren's syndrome has been reported. This study was undertaken in order to define the frequency of RTA and the possible pathogenetic mechanisms in a group of 21 randomly selected primary Sjögren's syndrome patients. RTA was found in 7 (33%) patients. The incomplete type of the disorder was the most frequent. It seems that the etiology of RTA is multifactorial. Renal excretion of monoclonal proteins and the immunologically-induced interstitial inflammation are the main possible factors of this renal tubular defect.Keywords
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