EXPRESSION OF BINDING-SITES FOR PEANUT AGGLUTININ DURING MURINE LYMPHOCYTE-B DIFFERENTIATION
- 1 January 1980
- journal article
- research article
- Vol. 40 (2) , 193-200
Abstract
Hemopoietic cells from several murine organs were examined for the presence of peanut agglutinin (PNA) receptors. Fetal liver and adlut bone marrow contained cells which were PHA+ but did not stain with conventional T [thymus-derived] and B [bone marrow-derived] markers. Some PNA+ cells were pre-B cells as shown by the presence of cytoplasmic Ig[immunoglobulin]M in the absence of cell surface Ig. Cells in the T lineage retained their PNA receptors during maturation although these became masked by sialic acid on mature peripheral blood T cells. Cells of the B lineage gradually lost their PNA receptors as they matured from pre-B to mature surface Ig positive B lymphocytes.This publication has 13 references indexed in Scilit:
- Binding of Peanut Lectin to Breast Epithelium, Human Carcinomas, and a Cultured Rat Mammary Stem Cell: Use of the Lectin as a Marker of Mammary DifferentiationJNCI Journal of the National Cancer Institute, 1979
- Abelson virus-transformed haematopoietic cell lines with pre-B-cell characteristicsNature, 1979
- Interaction of Peanut Agglutinin with Human Lymphocytes. Binding Properties and Topology of the Receptor SiteZeitschrift für Immunitätsforschung: Immunobiology, 1978
- Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins.Proceedings of the National Academy of Sciences, 1978
- PEANUT AGGLUTININ .1. NEW TOOL FOR STUDYING LYMPHOCYTE-T SUB-POPULATIONS1978
- Separation of mouse thymocytes into two subpopulations by the use of peanut agglutininCellular Immunology, 1976
- Early production of intracellular IgM by B-lymphocyte precursors in mouseNature, 1976
- The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea).Journal of Biological Chemistry, 1975
- On the specificity of lectins with a broad agglutination spectrum. II. Studies on the nature of the T-antigen and the specific receptors for the lectin of Arachis hypogoea (ground-nut).1969
- A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow CellsRadiation Research, 1961