Mhox and vertebrate skeletogenesis: The long and the short of it
- 1 September 1995
- Vol. 17 (9) , 750-753
- https://doi.org/10.1002/bies.950170903
Abstract
The development of the vertebrate skeleton is under complex genetic control, and good progress is being made towards identifying the genes responsible. A recent paper(1) contributes to this progress by describing transgenic mice in which the homeobox‐containing MHox gene has been disrupted. MHox(−/−) mice have a range of skeletal defects, involving loss or shortening of structures in the skull, face and limb. Puzzling features of the MHox(−/−) mutation, which has similar effects on bones with very different embryological origins and yet spares other bones completely, may hold clues to the mechanisms that shape the skeleton. MHox(−/−) mice, used in conjunction with other skeletal mutants, will be important tools for exploring these mechanisms further.Keywords
This publication has 25 references indexed in Scilit:
- Toward a molecular understanding of skeletal developmentCell, 1995
- Hox genes in vertebrate developmentPublished by Elsevier ,1994
- Muscle Homeodomain Protein MHox Inhibits Ternary Complex Formation at the c-fos Serum Response ElementBiochemical and Biophysical Research Communications, 1994
- Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamilyNature, 1994
- Genomic Organization and Chromosome Localization of the Murine Homeobox Gene PmxGenomics, 1994
- What do BMPs do in mammals? Clues from the mouse short-ear mutationTrends in Genetics, 1994
- Sonic hedgehog mediates the polarizing activity of the ZPACell, 1993
- Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbsCell, 1993
- Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response FactorScience, 1992
- Homeobox gene expression correlated with the bifurcation process of limb cartilage developmentNature, 1991