PERIARTERITIS NODOSA: REPORT OF A CASE TREATED WITH PARA-AMINOBENZOIC ACID

Publisher Website
Google Scholar
Abstract
In Aug., 1949, a 50.yr.-old white male with pathologically proven periarteritis nodosa and with typical clinical signs, including fever, anemia, eosinophilia and an elevated blood urea N, was treated with 20 g. of para-aminobenzoic acid (PABA) daily. After 22 days of therapy, his temp. reached normal and there was some improvement in the laboratory studies. About 3 weeks after the cessation of therapy, typical clinical signs returned. He was again treated with PABA and after 4 days, his temp. remained normal. Therapy was continued for 2 months. All symptoms disappeared and there was a return to normal of his hemogram and blood urea N. Urine continued to show a trace of albumin and a few casts. He remained well until Aug., 1951, when he developed typical bronchial asthma. In Jan., 1952, he was re-admitted to the hospital because of this complaint, and after a 2d injn. of a stock vaccine, he again developed typical signs and symptoms of periarteritis. Concurrent treatment with PABA and ACTH resulted in marked improvement. During his asymptomatic period, the only abnormality was a trace of albumin and a few casts in his urine. At the time of discharge from the hospital, his eosinophil count was 13% of the total white count.

This publication has 2 references indexed in Scilit: