Antibacterial activity of the cephamycin cefotetan: an in-vitro comparison with other -actam antibiotics

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Abstract
The cephamycin, cefotetan, was compared with other β-lactam antibiotics including the monocyclic β-lactam, azthreonam, against a total of 277 recent clinical isolates. Cefotetan had activity comparable to moxalactam against Staphylococcus aureus and against the Enterobacteriaceae, inhibiting all isolates except for Serratia marcescens and Enterobacter spp. at ⋜ 0.5 mg/l. Cefotetan was active against β-lactamase producing and non-β-lactamase producing Haemophilus influenzae (MIC 90 1 mg/l); was inactive against Pseudomonas aeruginosa (MIC 90 > 128 mg/l); and was eightfold less active than cefoxitin against the Bacteroides fragilis group. Azthreonam was as active as moxalactam against the Enterobacteriaceae and was more active than moxalactam against Ps. aeruginosa , inhibiting 90% of isolates at ⋜ 8 mg/l, but was inactive against the Bact. fragilis group (MIC 90 > 128 mg/l) and against Staphylo–coccus aureus (MIC 90 > 128 mg/l).

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