Protein Leakage from Mengovirus-Infected Cells.

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Abstract
Infection of guinea pig spleen cells with mengovirus resulted in the leakage of protein which indicates a reliable and quantitative measure of cellular injury. Experiments with actinomycin D and streptovitacin A suggested that virus-specific proteins are the cause of protein leakage, and tended to rule out the suppressive action of the viral genome as a primary factor. The appearance of extra-cellular virus and the earliest manifestation of CPE [cytopathic effects] preceded protein leakage by approximately 1 hr.

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