Identification of 1,25-Dihydroxycholecalciferol, a Form of Vitamin D 3 Metabolically Active in the Intestine
- 1 April 1971
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 68 (4) , 803-804
- https://doi.org/10.1073/pnas.68.4.803
Abstract
A biologically active vitamin D(3) metabolite ("peak V metabolite") more polar than 25-hydroxycholecalciferol has been isolated from chicken intestines in pure form as a mono(trimethylsilyl)ether derivative. The molecule has been identified as 1,25-dihydroxycholecalciferol by means of mass spectrometry, ultraviolet absorption spectrophotometry, and specific chemical reactions.Keywords
This publication has 13 references indexed in Scilit:
- 25,26-Dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activityBiochemistry, 1970
- 21,25-Dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on boneBiochemistry, 1970
- Metabolism and subcellular location of 25-hydroxycholecalciferol in intestinal mucosaBiochemistry, 1970
- Metabolism of vitamin D. A new cholecalciferol metabolite, involving loss of hydrogen at C-1, in chick intestinal nucleiBiochemical Journal, 1969
- Metabolites of Vitamin D3 and Their Biologic ActivityJournal of Nutrition, 1969
- Isolation and identification of 25-hydroxyergocalciferolBiochemistry, 1969
- Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3.Proceedings of the National Academy of Sciences, 1968
- 25-Hydroxycholecalciferol. A biologically active metabolite of vitamin D3Biochemistry, 1968
- The Association of a Metabolite of Vitamin D3 with Intestinal Mucosa Chromatin in VivoJournal of Biological Chemistry, 1968
- Biologically active metabolite of vitamin D3 from bone, liver, and blood serumJournal of Lipid Research, 1966