Inhibitory Effect of Fatty Acids on the Binding of Androgen Receptor and R1881.
- 1 January 1988
- journal article
- research article
- Published by Japan Endocrine Society in Endocrinologia Japonica
- Vol. 35 (1) , 93-96
- https://doi.org/10.1507/endocrj1954.35.93
Abstract
Unsaturated long chain fatty acids are known to inhibit the binding between estrogen and estrogen receptor, or progesterone and progesterone receptor in rat uterus. The effects of long chain fatty acids on the binding between androgen receptor of castrated rat prostate and 3H-R1881 were studied. The binding was not affected by saturated fatty acids such as palmitic acid (16:0) or stearic acid (18:0). But unsaturated fatty acids such as oleic acid (18:1), arachidonic acid (20:4) and docosahexaenoic acid(22:6) inhibited the binding between androgen receptor and 3H-R1881. The inhibitory effect of arachidonic acid was dose dependent. Scatchard analysis showed that the addition of arachidonic acid markedly decrease the number of binding sites of androgen receptor. But the dissociation constant was not affected. The inhibitory effect of arachidonic was not a competitive one.This publication has 3 references indexed in Scilit:
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- Potentiation of Estradiol Binding to Human Tissue Proteins by Unsaturated Nonesterified Fatty Acids*Endocrinology, 1986
- Inhibition of the binding of R-5020 and rat uterine progesterone receptors by long chain fatty acids.Endocrinologia Japonica, 1986