The Effect of Serotonin on Pepsin Inhibition by Duodenal Fat

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Abstract
The possible role of serotonin on pepsin secretion was evaluated [in dogs]. Serotonin appears to be a stimulator of pepsin since pretreatment with reserpine (which depletes serotonin stores) abolished the stimulatory effect of histamine on pepsin secretion, pretreatment with UML-491 [1-methyl-d-lysergic acid butanolamide tartrate], (a serotonin blocking agent at the effector level) augmented the pepsin inhibition induced by the intraduodenal infusion of fat and 5-hydroxytryptophan (a serotonin precursor) caused a significant stimulation of pepsin secretion. The mode of action of serotonin is probably by direct hormonal action on gastric chief cells.