Acute and Chronic Hyperosmolality
- 1 January 1975
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 32 (1) , 62-64
- https://doi.org/10.1001/archneur.1975.00490430084018
Abstract
Acute and chronic elevations in osmolality were induced in rats and mice. After 48 and 96 hours of hyperosmolality, rat brain glutamine concentration increased to between 210% and 230% of control. This increase may account for 20% of the previously postulated idiogenic osmols that enable the brain to resist volume changes. Cerebral metabolic rates were reduced in the brains of mice made acutely and chronically hyperosmotic in spite of normal levels of adenosine triphosphate and phosphocreatine.Keywords
This publication has 9 references indexed in Scilit:
- METABOLISM OF GLUCOSE, AMINO ACIDS, AND SOME RELATED METABOLITES IN THE BRAIN OF TOADS (BUFO BOREAS) ADAPTED TO FRESH WATER OR HYPEROSMOTIC ENVIRONMENTSJournal of Neurochemistry, 1973
- Activation of γ‐glutamyl transpeptidase by monovalent cationsFEBS Letters, 1973
- On the Enzymology of Amino Acid TransportScience, 1973
- Studies on Mechanisms of Cerebral Edema in Diabetic Comas. EFFECTS OF HYPERGLYCEMIA AND RAPID LOWERING OF PLASMA GLUCOSE IN NORMAL RABBITSJournal of Clinical Investigation, 1973
- Sodium ion movements and the spontaneous and electrically stimulated release of [3H]GABA and [14C]glutamic acid from rat cortical slicesBrain Research, 1972
- CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY1Journal of Neurochemistry, 1972
- Factors that limit brain volume changes in response to acute and sustained hyper- and hyponatremiaJournal of Clinical Investigation, 1968
- Effects of inorganic salts and of ouabain on some metabolic responses of rat cerebral cortex slices to cationic and electrical stimulationsCanadian Journal of Biochemistry, 1968
- Amino acids and the maintenance of osmotic equilibrium in brain tissueLife Sciences, 1966