DNA Interaction with Chiral Metal Complexes
- 1 January 1991
- journal article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 195-205
- https://doi.org/10.1080/07328319108046446
Abstract
Despite extensive study of DNA interaction with propeller–shaped metal complexes, such as the δ and Λ enantiomers of [Ru(l,10–phenanthroline)3]2+, the basis for their enantioselectivity, and even their binding modes, are not yet fully understood. 1H NMR studies of the interactions with the self–complementary oligonucleotide d(CGCGATCGCG)2 indicate that both enantiomers bind into the minor groove of t6e central AT-TA region, but with a rapid exchange between the bound and free 8tates. Flow linear dichroism (FLD) and circular dichroism (CD) show different binding geometries for the two enantiomers. These two geometries are found in natural DNA as well as in a number of different B form polynucleotides, virtually independent of base composition and of methylation. The DNA interaction with the [Ru(l,10– phenanthroline)3]2+ complexes will be reconsidered in the light of NMR, FLD, CD and fluorescence results.Keywords
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