Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
Open Access
- 1 January 1989
- journal article
- research article
- Published by The Company of Biologists in Development
- Vol. 105 (1) , 131-136
- https://doi.org/10.1242/dev.105.1.131
Abstract
The FGF-related proto-oncogene int-2 is implicated in mouse embryogenesis, since it is expressed in specific tissues during gastrulation and neurulation (Wilkinson et. al. 1988). Here, we describe the expression of this gene during subsequent fetal development, int-2 transcripts are restricted to Purkinje cells in the cerebellum and to regions of the developing retina containing early-stage differentiating cells. This high level expression is not detected in the mature cerebellum or retina. In addition, int-2 RNA is detected in the mesenchyme of the developing teeth and in sensory regions of the inner ear. This complex and dynamic pattern suggests multiple roles of this proto-oncogene during fetal development of the mouse.This publication has 33 references indexed in Scilit:
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