The Animal With an Eck Fistula

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Abstract
In dogs, after experimental anastomosis of the portal vein to the vena cava and occlusion of the portal vein at its entrance to the liver, characteristic symptoms occur, with deterioration of the animal and death within several months. The development of collateral circulation to the liver or the presence of portal-systemic collateral circulation prevents the symptoms and the deterioration. The author describes the effect of varying diet and surgical procedure upon the syndrome, amplifying the picture with results of analyses of blood for amino acids, urea, and ammonia, and of various tissues for 5-hydroxytrypta-mine. The Eck fistula animal shows an interesting relationship between intestinal, hepatic, and cerebral functions.

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