Biosynthesis of mycophenolic acid. Oxidation of 6-farnesyl-5,7-dihydroxy-4-methylphthalide in a cell-free preparation from Penicillium brevicompactum
- 1 January 1978
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 434
- https://doi.org/10.1039/c39780000434
Abstract
The conversion of 6-farnesyl-5,7-dihydroxy-4-methylphthalide (5) into mycophenolic acid (1) proceeds through the hydroxy-ketone (11) by oxidation of the central double bond.This publication has 3 references indexed in Scilit:
- Biosynthesis of mycophenolic acid. Substrate stereochemistry of farnesyl pyrophosphate: 5,7-dihydroxy-4-methylphthalide farnesyl transferase from Penicillium brevicompactumJournal of the Chemical Society, Chemical Communications, 1977
- Biosynthesis of mycophenolic acid. The synthesis of 6-farnesyl-5,7-dihydroxy-4-methylphthalide in a cell-free preparation from Penicillium brevicompactumJournal of the Chemical Society, Chemical Communications, 1977
- STUDIES ON BIOSYNTHESIS OF CHOLESTEROL .16. CHEMICAL SYNTHESIS OF 1-H23-2-C14- AND 1-D2-2-C14-TRANS-TRANS-FARNESYL PYROPHOSPHATE AND THEIR UTILIZATION IN SQUALENE BIOSYNTHESIS1962