THE UPTAKE IN THE PANCREATIC ISLETS OF NICOTINAMIDE, NICOTINIC ACID AND TRYPTOPHAN AND THEIR ABILITY TO PREVENT STREPTOZOTOCIN DIABETES IN MICE

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Abstract
The uptake of the NAD-precursors nicotinamide, nicotinic acid and tryptophan in the pancreatic islets of mice was studied by use of autoradiographic methods. The ability of these substances to prevent streptozotocin diabetes was studied in the same species. Only nicotinamide was strongly accumulated in the pancreatic islets and nicotinamide was also the only NAD-precursor which protected against the streptozotocin diabetes. Apparently there is a relationship between the ability of the NAD-precursors to be taken up in the pancreatic islets and their ability to prevent streptozotocin diabetes.

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