Value of Genetic Variants of Glucose-6-Phosphate Dehydrogenase in Tracing the Origin of Malignant Tumors

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Abstract
A CANCER is generally viewed as the uncontrolled proliferation of a single cell type within the body. Presumably, one or more tissue cells undergo a transformation that permits them to escape from normal control mechanisms. Little information is available, however, regarding the question of whether this change affects a single cell, which proliferates and represents the sole progenitor of the cancer, or whether the alteration affects numerous tissue cells. If the cancer is due to an unfortunate somatic mutation occurring more or less at random, it seems likely that a single cell would be the forerunner of the tumor. If, . . .