Impaired Peripheral Chemosensitivity and Acute Respiratory Failure in Arnold-Chiari Malformation and Syringomyelia

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Abstract
THE mechanism of alveolar hypoventilation complicating diseases of the central nervous system has generally been undefined or attributed to dysfunction of the medullary respiratory center.Studies of a patient with syringomyelia and Arnold-Chiari malformation, in whom an episode of nonprogressive pneumonia precipitated respiratory failure despite adequate ventilatory capacity, indicated that this complication was probably attributable to a total absence of hypoxic ventilatory drive due to cranial-nerve dysfunction that interrupted peripheral chemoreceptor afferents.Case ReportAn 18-year-old man with the diagnosis of Arnold-Chiari malformation and syringomyelia treated in 1970 with subtotal craniectomy and spinopleural shunt was admitted to Colorado General Hospital . . .

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