9,11-Cyclic acetal derivatives of (9S)-9-dihydroerythromycin A.
- 1 January 1989
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 42 (2) , 293-298
- https://doi.org/10.7164/antibiotics.42.293
Abstract
A series of 9,11-cyclic acetal derivatives of (9S)-9-dihydroerythromycin a (4) have been prepared and their antibacterial activities compared to those of erythromycin A and 9-dihydroerythromycin A. Many of the cyclic acetal derivatives showed better antibacterial activity than their parent 4. In particular, the acetaldehyde acetal (9-O,11-O-ethylidene-9-dihydroerythromycin A) (8b) showed good antibacterial activity in comparison with erythromycin A but was not sufficiently improved in vivo to warrant progression.This publication has 1 reference indexed in Scilit:
- Erythromycin. VI. Degradation Studies1Journal of the American Chemical Society, 1956