Active Inhibition of Plasma Cell Development in Resting B Cells by Microphthalmia-associated Transcription Factor
Open Access
- 28 June 2004
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 200 (1) , 115-122
- https://doi.org/10.1084/jem.20040612
Abstract
B cell terminal differentiation involves development into an antibody-secreting plasma cell, reflecting the concerted activation of proplasma cell transcriptional regulators, such as Blimp-1, IRF-4, and Xbp-1. Here, we show that the microphthalmia-associated transcription factor (Mitf) is highly expressed in naive B cells, where it antagonizes the process of terminal differentiation through the repression of IRF-4. Defective Mitf activity results in spontaneous B cell activation, antibody secretion, and autoantibody production. Conversely, ectopic Mitf expression suppresses the expression of IRF-4, the plasma cell marker CD138, and antibody secretion. Thus, Mitf regulates B cell homeostasis by suppressing the antibody-secreting fate.Keywords
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