CIRCULATORY EFFECTS OF PROSTAGLANDIN ENDOPEROXIDE ANALOGUES STUDIED IN THE DOG DURING LEFT VENTRICULAR BYPASS

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Abstract
1 Intravenous administration of both the 9α,11α-(epoxymethano) and 11α,9α-(epoxymethano) analogues of prostaglandin H2 (0.25 üg/kg) produced a prominent rise in pulmonary arterial pressure and a moderate increase in systemic arterial pressure. 2 Direct administration of the endoperoxide analogues (1.25 μg/kg) into the bypass reservoir produced a greater rise in systemic arterial pressure and less prominent rise in pulmonary arterial pressure. 3 An intravenous dose of prostaglandin F2α that was 20 times larger was needed to produce a comparable rise in pulmonary arterial pressure. 4 The pulmonary and systemic pressor responses produced by the endoperoxide analogues were due to a direct increase in the vascular resistance.