Comparison of Metocurine and Pancuronium—Myocardial Tension-Time Index during Endotracheal Intubation

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Abstract
The anesthetic management of patients undergoing coronary artery revascularization procedures must be conducted with meticulous attention to factors that increase myocardial O2 demand. With the TTI [tension-time index] it is possible to assess effects of anesthetic techniques on myocardial O2 demand. The cardiovascular effects of pancuronium bromide and metocurine iodide were studied in intubated patients during moderate levels of halothane-N2O anesthesia. Both relaxants produce good clinical levels of relaxation, but only metocurine has minimal cardiovascular effects. The effects of metocurine and pancuronium on changes in the myocardial TTI evoked by tracheal intubation in patients with coronary artery disease were compared.

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