Genetics of the epilepsies
- 1 April 1999
- journal article
- review article
- Published by Wolters Kluwer Health in Current Opinion in Neurology
- Vol. 12 (2) , 177-182
- https://doi.org/10.1097/00019052-199904000-00008
Abstract
Epilepsies, like other common diseases, have complex inheritance, and molecular genetic studies in such conditions are difficult. There has been recent success in identifying the molecular basis of certain epilepsies, particularly in those syndromes with autosomal dominant inheritance. All four genes discovered to date for idiopathic epilepsies code for ion channel subunits, either ligand-gated or voltage-gated. The idiopathic epilepsies thus appear, at least in part, to be a family of channelopathies. Curr Opin Neurology 12:177-182.Keywords
This publication has 48 references indexed in Scilit:
- A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)Human Molecular Genetics, 1999
- Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular HeterotopiaNeuron, 1998
- Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsyNature Genetics, 1998
- Genomics and human disease—variations on variationNature Genetics, 1998
- A Novel CNS Gene Required for Neuronal Migration and Involved in X-Linked Subcortical Laminar Heterotopia and Lissencephaly SyndromeCell, 1998
- doublecortin, a Brain-Specific Gene Mutated in Human X-Linked Lissencephaly and Double Cortex Syndrome, Encodes a Putative Signaling ProteinCell, 1998
- Dodecamer repeat expansion in cystatin B gene in progressive myoclonus epilepsyNature, 1997
- Epilepsies with single gene inheritanceBrain & Development, 1997
- The Future of Genetic Studies of Complex Human DiseasesScience, 1996
- Mutations in the Gene Encoding Cystatin B in Progressive Myoclonus Epilepsy (EPM1)Science, 1996