MULTICENTRIC GIANT LYMPH-NODE HYPERPLASIA, KAPOSIS SARCOMA, AND LYMPHOMA

  • 1 January 1985
    • journal article
    • research article
    • Vol. 109  (11) , 1013-1018
Abstract
We studied two cases of a recently recognized systemic lymphoproliferative disease with morphological features of Castleman''s disease: multicentric giant lymph node hyperplasia. Both patients developed Kaposi''s sarcoma and had laboratory evidence of immune abnormalities, including reversed T4 to T8 ratios. One patient''s disease had a subacute course with fevers of unknown origin, mucocutaneous candidiasis, and progressive thrombocytopenia, while the other patient''s disease had a fulminant course with anemia, thrombocytopenia, and splenic lymphoma. Both patients were elderly, and both died of complications of multicentric giant lymph node hyperplasia.