CIRCULATING CK-MB AND CK-BB ISOENZYMES AFTER PROSTATE RESECTION

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 26  (1) , 55-59
Abstract
The effect of prostate resection on serum creatine kinase and lactate dehydrogenase (EC 1.1.1.27) isoenzymes was studied in 33 patients. Two hours after their operations, 2/3 of these patients had increased total creatine kinase activity. The MB isoenzyme was demonstrated in sera of 66% of the patients and the BB isoenzyme in 76%. MB content varied at 1-7% of total creatine activity, the average activity being 7.4 .+-. 6 (SD) U/l. BB content varied at 1-29% of the total creatine kinase activity, the average activity being 8.5 .+-. 5.4 U/l. No patients showed evidence of cardiac damage. In contrast to the enzyme changes associated with cardiac injury, MB isoenzyme seen after prostate resection is usually associated with the appearance of BB activity. The ratio of lactate dehydrogenase isoenzymes 1 and 2 was inverted in only 5 of the 33 patients and appeared to correlate with the degree of hemolysis in the postoperative sera. The prostate contains all 3 creatine kinase isoenzymes, BB predominating.

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