Pathogenesis of Peptic Ulcer and Implications for Therapy
- 29 March 1990
- journal article
- review article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 322 (13) , 909-916
- https://doi.org/10.1056/nejm199003293221307
Abstract
ALTHOUGH several features of peptic ulcer disease have been elucidated over the past few years, new questions have replaced those that have been answered. Some of the factors that may predispose people to the development of peptic ulcers have been identified, but how they produce their effects and how they can be combated therapeutically remain unclear. This seminar briefly reviews current knowledge about the pathogenesis of peptic ulcers and discusses strategies for treatment.Defense of Normal Mucosa against Acid and Peptic InjuryThree basic levels of defense underlie the remarkable ability of normal gastroduodenal mucosa to resist injury from the . . .Keywords
This publication has 61 references indexed in Scilit:
- Effect of Omeprazole and Ranitidine on Ulcer Healing and Relapse Rates in Patients with Benign Gastric UlcerNew England Journal of Medicine, 1989
- The Physiology of Gastric Acid SecretionNew England Journal of Medicine, 1988
- The Role of Smoking in Peptic Ulcer DiseaseJournal of Clinical Gastroenterology, 1988
- Impaired Proximal Duodenal Mucosal Bicarbonate Secretion in Patients with Duodenal UlcerNew England Journal of Medicine, 1987
- Acid secretory capacity and plasma gastrin concentration after administration of omeprazole to normal subjectsAlimentary Pharmacology & Therapeutics, 1987
- NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND BLEEDING PEPTIC ULCERThe Lancet, 1986
- Smoking and Ulcers — Time to QuitNew England Journal of Medicine, 1984
- Cimetidine, Cigarette Smoking, and Recurrence of Duodenal UlcerNew England Journal of Medicine, 1984
- Randomised crossover trial of tripotassium dicitrato bismuthate versus high dose cimetidine for duodenal ulcers resistant to standard dose of cimetidine.Gut, 1984
- Late Mortality after Surgery for Peptic UlcerNew England Journal of Medicine, 1982