STUDIES ON THE CAVERNOUS SINUS SYNDROME

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Abstract
A combined Scandinavian-British series of 672 cases of primary malignant nasopharyngeal tumors has been submitted to a clinical analysis in order to contribute towards an earlier diagnosis of such tumors, whose prognosis has not improved during the past 20 years. Thirty-six percent presented ophthalmoneurological signs and symptoms. After a quantitative, qualitative and chronological review of the ophthalmoneurological phenomena, suggestions are made with regard to when, how and why these may contribute towards earlier diagnosis. It is shown that the presence of the cavernous sinus syndrome (ophthalmoplegia concurrently with trigeminal neuralgia) is clinically important and is found in 20% of cases. The prognosis of malignant nasopharyngeal tumors complicated by ophthalmoneurological phenomena is extremely poor, and a curative result is very rarely obtained. In view of the newer and promising radiotherapeutic possibilities now available, there is added reason to intensify the efforts at earlier recognition and consequently at earlier treatment of these patients.

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