Structural insights into serpin—protease complexes reveal the inhibitory mechanism of serpins
- 1 May 1997
- journal article
- research article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 4 (5) , 354-357
- https://doi.org/10.1038/nsb0597-354
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- The Inhibition Mechanism of SerpinsPublished by Elsevier ,1995
- Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme IntermediatesPublished by Elsevier ,1995
- Time-resolved polarized fluorescence spectroscopy studies of plasminogen activator inhibitor type 1: conformational changes of the reactive center upon interactions with target proteases, vitronectin and heparinBiochemistry, 1995
- Structural basis for serpin inhibitor activityProteins-Structure Function and Bioinformatics, 1995
- The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactionsNature Structural & Molecular Biology, 1994
- Immunologic evidence for insertion of the reactive-bond loop of antithrombin into the A .beta.-sheet of the inhibitor during trapping of target proteinasesBiochemistry, 1993
- Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet ABiochemistry, 1992
- Serpins: Mobile conformations in a family of proteinase inhibitorsCurrent Opinion in Structural Biology, 1992
- Natural protein proteinase inhibitors and their interaction with proteinasesEuropean Journal of Biochemistry, 1992
- Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpinsBiochemistry, 1989