Early Activation Signals in Endothelial Cells
- 1 March 1997
- journal article
- review article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 17 (3) , 423-428
- https://doi.org/10.1161/01.atv.17.3.423
Abstract
Abstract With limitation to the “proinflammatory program” induced in endothelial cells by exposure to interleukin-1, tumor necrosis factor, and interleukin-6, we review the available data on the signaling for these three cytokines, from receptor engagement to induction of gene transcription. Only a few molecular pathways have been characterized so far, and key issues in endothelial biology, such as endothelial specificity of gene expression and heterogeneity of different endothelial populations, remain largely unexplored.Keywords
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