HLA-B27 RELATED ARTHRITIS AND BOWEL INFLAMMATION .1. SULFASALAZINE (SALAZOPYRIN) IN HLA-B27 RELATED REACTIVE ARTHRITIS

  • 1 January 1985
    • journal article
    • research article
    • Vol. 12  (2) , 287-293
Abstract
Sulfasalazine was given to 15 HLA-B27 positive patients with asymmetrical pauciarticular arthritis and enthesopathies resistant to nonsteroidal antiinflammatory drugs (NSAID). In 11 patients, long lasting remission of inflammatory and biological variables was obtained after 3-12 mo. of treatment. In the other 4 patients significant improvement of the clinical and biological variables was observed. In the 7 patients on whom ileocolonoscopy was performed, inflammatory signs were seen in the terminal ileum or ileocecal valve, suggestive of inflammatory bowel disease (IBD). Sulfasalazine improves the intestinal symptoms of IBD; it is also beneficial in HLA-B27 related arthropathies resistant to NSAID. No significant adverse reactions were encountered. These findings are encouraging but have to be confirmed in a double blind controlled study.

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