Enzymatic Evidence for Intrinsic Oxytocic Activity of the Pressor-Antidiuretic Hormone

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Abstract
It was shown that trypsin had no effect on the activity of oxytocin but destroyed both the pressor and oxytocic activities of arginine-vasopressin. These conclusions offer enzymatic evidence, in addition to the evidence already obtained from analytical and electrophoretic studies, for the inherent oxytocic activity of arginine-vasopressin. It was also demonstrated that a lysine-vasopressin prepn. possessed oxytocic activity and that this activity was destroyed with the pressor activity by trypsin.

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