Synthesis of Spiro Diphosphines and Their Application in Asymmetric Hydrogenation of Ketones
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- 21 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 125 (15) , 4404-4405
- https://doi.org/10.1021/ja029907i
Abstract
Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100 000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones.Keywords
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