Murine Model of Infection by Tropheryma whipplei
- 1 August 2006
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 74 (8) , 4915-4917
- https://doi.org/10.1128/iai.00283-06
Abstract
We developed an animal model reproducing several aspects of Whipple's disease. Immunocompetent mice were persistently infected with Tropheryma whipplei , its etiological agent, and developed liver granulomas. SCID mice were infected similarly but did not develop tissue lesions. The delayed clearance of T. whipplei suggests a protective role for innate immunity.Keywords
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