EXPERIMENTAL AND CLINICAL STUDIES OF ERGOTAMINE
- 1 April 1931
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1908)
- Vol. 47 (4) , 612-632
- https://doi.org/10.1001/archinte.1931.00140220101007
Abstract
Ergotamine and the closely related and pharmacologically similar ergotoxin constitute the principal alkaloids of ergot and exhibit all the effects of that drug on the uterus. In addition they have been shown to exert an effect on various parts of the sympathetic nervous system, in particular, a paralyzing or depressing action on the motor elements of that system that are stimulated by epinephrine. Briefly, in animals they not only antagonize the pressor effect of epinephrine on the systemic arteries, but under suitable conditions cause a reversal of the usual effect of epinephrine on the blood pressure.1Ergotamine inhibits the dilator effect of epinephrine on the coronaries,2and by its effect on the sympathetic nerves of the heart is said to slow the rate of sinus rhythm3and to neutralize the accelerator action of epinephrine.4In addition, ergotamine has been reported both to lower5and to raise β the blood sugarThis publication has 0 references indexed in Scilit: