Mucus Production and Ciliary Transport Activity In Vivo Studies Using the Chicken

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Abstract
A new technique for studying in vivo mucus transport and mucus production has been developed using the chicken. This technique is based on the observation that the trachea is easily exteriorized (into the chicken’s mouth) and experiments conducted on an in situ tissue. This procedure may be repeated without any apparent harm to the chicken. Exposing animate to smoke from regular or carbon filter cigarettes once a day for 32 days does not appear to produce permanent impairment in ciliary function. Mucus output was markedly increased during the period of smoke exposure. These in vivo studies indicate that gas-phase components (particularly hydrogen cyanide [HCN] and acrolein) are of major importance in the inhibition of ciliary transport and that appropriate filters can significantly reduce this inhibitory effect, but not the increase in mucus production observed during smoking.

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