Valproic acid versus ethosuximide in the treatment of absence seizures

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Abstract
Valproic acid (VPA) and ethosuximide (ESM) were compared in a double-blind, response-conditional crossover study of absence seizures in 16 naive (previously untreated for absence seizures) and 29 refractory patients (18 male and 27 female; 4-18 yr of age). In the naive patients VPA was as effective as ESM in reducing generalized spike-wave discharges on the telemetered EEG. Adverse reactions to VPA or ESM were generally mild and responded to withdrawal or dosage reduction of the drug.