Some pyrrolidines and azacycloheptanes related to reversed esters of pethidine
- 1 March 1965
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 17 (3) , 157-166
- https://doi.org/10.1111/j.2042-7158.1965.tb07634.x
Abstract
The preparation of some N-substituted 3-phenylpyrrolidin-3-ols and their derivatives is described, and the hot-plate analgesia activities in mice of these compounds and related azacycloheptane derivatives reported. The effect of changes in ring size upon the analgesic activities of 4-phenylpiperidine derivatives is discussed.Keywords
This publication has 11 references indexed in Scilit:
- Studies in Alkyl-Oxygen Heterolysis. Some 4-Alkoxypiperidines Related to Reversed Esters of PethidineJournal of Medicinal Chemistry, 1965
- 983. Synthesis and reactions of some azacycloheptan-4-olsJournal of the Chemical Society, 1964
- Analgetics Based on the Pyrrolidine Ring. II.Journal of Medicinal Chemistry, 1962
- Chemistry and Pharmacology of 4-Alkoxy-piperidines Related to Reversed Esters of PethidineJournal of Medicinal Chemistry, 1961
- Analgetics Based on the Pyrrolidine RingJournal of Medicinal Chemistry, 1961
- Alkyl-oxygen heterolysis in 4-aryl and 4-heteroaryl-4-piperidinols and estersTetrahedron, 1961
- Alpha- and Beta-Prodine Type CompoundsJournal of Medicinal Chemistry, 1959
- Synthéses Dans le Domaine de L'Azepindole I. Nouvelle synthèse de la 1 ‐Benzyl‐1‐Azacycloheptan‐4‐oneBulletin des Sociétés Chimiques Belges, 1958
- Some Physico-Chemical Factors in Drug ActionJournal of Pharmacy and Pharmacology, 1957
- Synthese und analgetische Wirkung einiger 1‐Methyl‐4‐phenyl‐piperidin‐(4)‐alkylsulfone. 1. MitteilungHelvetica Chimica Acta, 1952