Gamma-Ray-Induced Permeability Changes in Relation to Early Mortality in the Chick

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Abstract
In the 3-day-old chick, early mortality (death within 1 to 2 days) with Co60 [gamma] -irradiation is characterized by hypotension, sluggish circulation, hemorrhage, and edema. Radiation-induced increase in vascular permeability was indicated by rapid alterations in plasma proteins concentration. Loss of albumin began 10 minutes after exposure to 1400 r and continued until death. Plasma volume loss probably occurred after decreased albumin concentration. By 24 hours, more than 99% mortality had occurred in the 1400 r group. After 700 r, the loss of plasma albumin was more gradual and began to return to normal levels by 24 hours. In this group, less than 10% mortality occurred in the early period. With radiation extended over a longer exposure period (for example, 24 hours), a much longer dose was required to produce a comparable protein loss. Only after a 24-hour protracted dose of 12,800 r could a similar albumin loss or early mortality be demonstrated. This indicates that these permeability changes are dependent on exposure time as well as on delivered dose. It is suggested that the rate of protein loss and subsequent loss in plasma volume may be the factors that are critical for survival.

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