Diterpenoids. XXVII. Synthesis of 11-Methoxy-diterpenoids.(2). Synthesis of 11-Methoxy-dehydroabietic Acid Derivatives

1 January 1973

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 21 (3) , 653-658
https://doi.org/10.1248/cpb.21.653

Abstract

7-Oxo-dehydroabietamide (XI) derived from l-abietic acid (III) was converted to methoxycyano acid (XVI) via cyano lactone (XIII) and the intramolecular cyclization of XVI gave the expected 11-methoxy-7-oxo-dehydroabietonitrile (XVII). The cyclized compound (XVII) was converted to some 11-methoxy-dehydroabietic acid derivatives, which could be regarded as potential intermediates for synthesis of natural products having 11-hydroxyabietane skeleton.

Keywords

NATURAL PRODUCTS
DITERPENOIDS
CYCLIZED
XVII
METHOXY
DEHYDROABIETIC
POTENTIAL INTERMEDIATES
HYDROXYABIETANE SKELETON
CYANO LACTONE

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