ACUTE ENERGY DEPRIVATION IN MAN - EFFECT ON SERUM IMMUNOGLOBULINS ANTIBODY-RESPONSE, COMPLEMENT FACTORS 3 AND 4, ACUTE PHASE REACTANTS AND INTERFERON-PRODUCING CAPACITY OF BLOOD-LYMPHOCYTES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 30  (1) , 50-55
Abstract
The effects of 10 days of total energy deprivation on serum levels of immunoglobulins [Ig], antibodies acute phase reactants and on interferon production were evaluated in 14 healthy, normal-weight males. A significant depression was noted of the serum levels of complement factor 3 [C3], haptoglobin and orosomucoid. The titers of mercaptoethanol-sensitive specific antibodies to flagellin were higher in the subjects inoculated at the end of the starvation period than in controls and those inoculated at the start of the period. The serum levels of IgG, IgM, IgA, IgE, .alpha.-1-antitrypsin and C4, and the interferon-producing capacity of blood lymphocytes, were not changed. Ten days of total energy deprivation depresses the serum levels of several acute phase reactants and re-feeding may enhance antibody production.