A zinc-containing fiber system of thalamic origin

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Abstract
Zinc-containing neurons are cells that sequester zinc pre-synaptically and release it when active. Previously such neurons have been found almost exclusively in cerebro-cortical and amygdalar regions. Here we describe a thalamo-cortical pathway that is zinc-containing, namely, the projection from the anterodorsal nucleus of the thalamus to the subicular cortex. The pathway was identified by the zinc-specific retrograde transport methods; its addition to the zinc-containing cerebral circuitry reinforces the association of the zinc-containing terminals with cortico-limbic systems.
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