Prazosin first dose phenomenon during combined treatment with a beta- adrenoceptor blocker in hypertensive patients.
Open Access
- 1 June 1982
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 13 (6) , 865-870
- https://doi.org/10.1111/j.1365-2125.1982.tb01880.x
Abstract
1 The antihypertensive effect of prazosin has been studied in three groups of hypertensive patients. 2 The drug caused a significant reduction of blood pressure both as monotherapy and combined with alprenolol. 3 The effect of prazosin on blood pressure was more marked at the first dose and especially in combination with alprenolol. 4 No pharmacokinetic interaction between prazosin and alprenolol was observed. 5 Prazosin exhibits an exaggerated first dose effect together with alprenolol. Smaller starting doses of prazosin in combination therapy with beta-adrenoceptor blockers are warranted.This publication has 21 references indexed in Scilit:
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